首页> 外国专利> The drug composition consisted of 3 beta hydroxyl 17 - (L- hbenzimidazole -1- radical) Andros Andros alpha - 16 diene.

The drug composition consisted of 3 beta hydroxyl 17 - (L- hbenzimidazole -1- radical) Andros Andros alpha - 16 diene.

机译:该药物组合物由3-β羟基17-(L-苯并咪唑-1-基)Andros Androsα-16二烯组成。

摘要

Benzoazoles steroids C17, pyrimidinoazoles (azabenzoazoles) and two azazines were introduced.Their synthesis methods are also described, including the one-step reaction method_________addition - "replacement" The 3-acetoxy-ointment "formylandrosta-chloro-16-17-16-diene or analogues, benzoxazoles or pyrimidinoazole and neutrophil methods have a reactive cross-linking kappa alpha_alpha lambda_" Palladium research iodoandrosta - 17-5,16 diallyl -3- alcohol or analogue of two aza phenyl three butyltin. These compounds are powerful inhibitors and powerful competitors for human CYP enzyme 17, androgen (AR), collectors and primitive mutants Type. These compounds can be used in the treatment of human prostate cancer.
机译:介绍了苯并唑类固醇C17,嘧啶基吡唑(氮杂苯并唑)和两种氮嗪。它们的合成方法也有所描述,包括一步法_________加成-“取代” -3-乙酰氧基软膏-“ formlandandrosta-chloro-16-17- 16-二烯或类似物,苯并恶唑或嘧啶基咪唑和嗜中性粒细胞方法具有反应性交联的κα_alpha_alpha钯研究碘代安德罗斯塔-17-5,16二烯丙基-3-醇或类似的二氮杂苯基三丁基锡。这些化合物是人类CYP酶17,雄激素(AR),捕收剂和原始突变体Type的有力抑制剂和有力竞争者。这些化合物可用于治疗人类前列腺癌。

著录项

  • 公开/公告号CY1115910T1

    专利类型

  • 公开/公告日2017-01-25

    原文格式PDF

  • 申请/专利权人 UNIVERSITY OF MARYLAND BALTIMORE;

    申请/专利号CY201511000054T

  • 发明设计人 NJAR VINCENT;BRODIE ANGELA;

    申请日2015-01-20

  • 分类号C07J43/00;A61K31/58;A61P35/00;

  • 国家 CY

  • 入库时间 2022-08-21 13:39:34

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