___h_2 - (__ a_-6-____) and what are the pharmaceutical ingredients

摘要

The present invention relates to the substituted 2-(___ alpha_) - 6-_lambda_) - theta_a_chemical formula I, in which AR, R2, R3 and R4 are in the prescribed claim.Compounds of chemical formula I are the angiotensin system alpha__ _ alpha__ rho_sodium-calcium (NCX) system, especially alpha_ _ alpha__ sodium-calcium system. The 1 subtype (NCX1) is suitable for the interference of intracellular calcium homeostasis in the treatment of many diseases, such as a The heart failure and stroke.The present invention also relates to the chemical formula I used in the preparation of these compounds as pharmaceutical compositions and slopes. Y contains.