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A derivative of synthetic cannabinoid, the method of its preparation and use

机译:合成大麻素的衍生物,其制备方法和用途

摘要

The invention relates to the newly prepared derivatives of synthetic cannabinoids, whose structure contains a short connecting bridge bearing the carboxylic functional group, and chemical processes leading to the preparation of such compounds. These derivatives of synthetic cannabinoids can be advantageously used for conjugation with a fluorescent mark, which would then allow for visualization of interactions of thus labelled ligands with cannabinoid receptors, or for the preparation of immunogens by conjugation with the carrier protein. The polyclonal rabbit antibodies obtained from immunized laboratory animals can be applied in the development of fast, user-friendly formats of immunochemical assays LFIA (Lateral-Flow Immunochromatographic Assay).
机译:本发明涉及新制备的合成大麻素衍生物,其结构包含带有羧基官能团的短连接桥,以及涉及制备此类化合物的化学方法。合成大麻素的这些衍生物可以有利地用于与荧光标记的缀合,然后可以可视化如此标记的配体与大麻素受体的相互作用,或用于通过与载体蛋白缀合来制备免疫原。从免疫实验动物获得的多克隆兔抗体可用于开发快速,用户友好型的免疫化学测定LFIA(横向流动免疫色谱测定)。

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