PHARMACEUTICAL COMPOSITION BASED ON CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS

摘要

Provided is a pharmaceutical composition comprising at least one CRTH2 antagonist and at least one proton pump inhibitor selected from the group consisting of omeprazole, esomeprazole, lansoprazole, dexlansoprazole, pantoprazole, and rabeprazole, or pharmaceutically acceptable salts thereof, wherein said CRTH2 antagonist is a compound of general formula (I); ;wherein said substituents are defined is the claims, or a pharmaceutically acceptable salt thereof. Furthermore, provided are a kit for the treatment of eosinophilic esophagitis (EoE) comprising said composition and a method for preventing, treating, or ameliorating EoE in an individual, comprising administering to the individual a therapeutically effective amount of said composition. Also disclosed is the use of said composition for preparing and agent for preventing, treating, or ameliorating EoE.