;where R is C1-C3 alkyl."/> ALKYL (S)-1-((S)-2-{5-4-(4-{2-(S)-1-((S)-2-METHOXYCARBONYLAMINO-3-METHYL-BUTYRYL)PYRROLIDINE-2-YL-3H-IMIDAZOLE-4-YL}BUTA-1,3-DIENYL)PHENYL-1H-IMIDAZOLE-2-YL}PYRROLIDINE-1-CARBONYL)-2-METHYL-PROPYLCARBAMATE NAPHTHALENE-1,5-DISULFONATE, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT AND METHOD FOR TREATMENT OF VIRAL DISEASES
首页> 外国专利> ALKYL (S)-1-((S)-2-{5-4-(4-{2-(S)-1-((S)-2-METHOXYCARBONYLAMINO-3-METHYL-BUTYRYL)PYRROLIDINE-2-YL-3H-IMIDAZOLE-4-YL}BUTA-1,3-DIENYL)PHENYL-1H-IMIDAZOLE-2-YL}PYRROLIDINE-1-CARBONYL)-2-METHYL-PROPYLCARBAMATE NAPHTHALENE-1,5-DISULFONATE, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT AND METHOD FOR TREATMENT OF VIRAL DISEASES

ALKYL (S)-1-((S)-2-{5-4-(4-{2-(S)-1-((S)-2-METHOXYCARBONYLAMINO-3-METHYL-BUTYRYL)PYRROLIDINE-2-YL-3H-IMIDAZOLE-4-YL}BUTA-1,3-DIENYL)PHENYL-1H-IMIDAZOLE-2-YL}PYRROLIDINE-1-CARBONYL)-2-METHYL-PROPYLCARBAMATE NAPHTHALENE-1,5-DISULFONATE, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT AND METHOD FOR TREATMENT OF VIRAL DISEASES

机译:烷基[(S)-1-((S)-2- {5- [4-(4- {2-[(S)-1-((S)-2-METHOXYCARBOMINLAMINO-3-METHYL-BUTYRYL)PYRROLIDINE -2-YL] -3H-咪唑-4-YL} BUTA-1,3-二烯基]苯基] -1H-咪唑-2-YL}吡咯烷-1-羰基)-2-甲基-丙烯基]氨基甲酸萘-1 ,5-二磺酸盐,药物组合物,药物和治疗病毒性疾病的方法

摘要

The present invention relates to NS5A inhibitors, to a novel pharmaceutical composition, to an antiviral medicinal agent, and to a method for the prevention and treatment of viral diseases, particularly those caused by the hepatitis C (HCV) and hepatitis GBV-C viruses. Proposed are alkyl [(S)-1-((S)-2-{5-[4-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)pyrrolidine-2-yl]-3H-imidazole-4-yl}buta-1,3-dienyl)phenyl]-1H-imidazole-2-yl}pyrrolidine-1-carbonyl)-2-methyl-propyl]carbamate naphthalene-1,5-disulfonate of general formula 1, optionally in crystalline or polycrystalline form:; ;where R is C1-C3 alkyl.
机译:本发明涉及NS5A抑制剂,新型药物组合物,抗病毒药物以及预防和治疗病毒疾病的方法,特别是由丙型肝炎(HCV)和GBV-C型肝炎病毒引起的疾病。提出了烷基[(S)-1-((S)-2- {5- [4-(4- {2-[(S)-1-((S)-2-甲氧羰基氨基-3-甲基-丁酰基)吡咯烷-2-基] -3H-咪唑-4-基} buta-1,3-二烯基)苯基] -1H-咪唑-2-基}吡咯烷-1-羰基)-2-甲基-丙基]氨基甲酸萘通式1的-1,5-二磺酸盐,任选为晶体或多晶形式: <图像文件=“ IMGA0002.GIF” he =“ 49” imgContent =“绘图” imgFormat =“ GIF” wi =“ 114” /> ;其中R是C 1 -C 3 烷基。

著录项

  • 公开/公告号EA026861B1

    专利类型

  • 公开/公告日2017-05-31

    原文格式PDF

  • 申请/专利权人 ALEXANDRE VASILIEVICH;ANDREY ALEXANDROVICH;

    申请/专利号EA20150000740

  • 发明设计人 ALEXANDRE VASILIEVICH;

    申请日2014-02-04

  • 分类号C07D403/04;C07C303/32;A61K31/4178;A61P31/12;

  • 国家 EA

  • 入库时间 2022-08-21 13:39:15

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