COMPOSITION WITH MULTI-MODE SURVIVAL, CONTAINING DOXYLAMINE AND PYRIDOXIN AND / OR THEIR METABOLITES OR SALT

摘要

A solid oral dosage form is described, which contains a core containing a doxylamine component and an enteric-coated pyridoxine component. A solid oral dosage form further comprises two active ingredient-containing coatings surrounding the enteric coating, the coatings containing the active ingredient being separated from each other by an intermediate coating, one of the two containing the active ingredient coatings contains the doxylamine component and does not contain the pyridoxine component, and the second of The two coatings containing the active ingredient contain the pyridoxine component and do not contain the doxylamine component. Also described is the use of a solid oral dosage form to alleviate the symptoms of nausea and vomiting, for example in the case of nausea and vomiting during pregnancy (TRD).