HUMAN PAPILLOMA VIRUS ANTIGENES WITH GOOD IMMUNOLOGICAL PROPERTIES AND CONTAINING THEIR VACCINE

摘要

The present invention relates to genes encoding various HPV antigens of several serotypes. The gene of the present invention produces virus-like particles with improved immunological properties and a quaternary structure. The present invention also relates to a suitable host cell, preferably P. pastoris, with a high copy number of genes encoding various HPV antigens of several serotypes. The present invention also relates to a vaccine against HPV antigens with an improved immunization schedule, wherein the dosage regimen of the vaccine is simplified and the dose of antigens is reduced. The present invention also relates to an improved composition of a human papillomavirus vaccine obtained with yeast.