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Method of constructing a library of a protein scaffold based on fibronectin type iii domain and libraries produced thereby
Method of constructing a library of a protein scaffold based on fibronectin type iii domain and libraries produced thereby
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机译:基于III型纤连蛋白结构域构建蛋白质支架文库的方法和由此产生的文库
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摘要
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
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