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Methods for detecting cancer and determining prognosis and survival probabilities and ratio based biomarkers for use therein
Methods for detecting cancer and determining prognosis and survival probabilities and ratio based biomarkers for use therein
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机译:用于检测癌症并确定预后和生存概率的方法以及用于其中的基于比率的生物标志物
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摘要
Compositions, methods and kits are described for identifying biomolecules (e.g., proteins and nucleic acids) expressed in a biological sample that are associated with the presence, development, or progression of a disease (such as cancer), or more generally determination of the etiology or risk factors associated with a disease. Sample types analyzed by the disclosed methods include but are not limited to archival tissue blocks that have been preserved in a fixative, tissue biopsy samples, tissue microarrays, and so forth. The methods disclosed herein correlate expression profiles of biomolecules with various disease types, and allow for the determination of relative survival rates; in some embodiments, the methods permit determination of survival rates for a subject with cancer.; In other embodiments, the disclosure relates to methods for evaluating therapeutic regimes for the treatment, such as treatment of cancer.
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