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Predictive and prognostic biomarkers related to anti-angiogenic therapy of metastatic colorectal cancer
Predictive and prognostic biomarkers related to anti-angiogenic therapy of metastatic colorectal cancer
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机译:与转移性结直肠癌抗血管生成治疗有关的预测性和预后性生物标志物
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摘要
The present invention provides methods for treating metastatic cancer comprising identifying subjects who will respond favorably to anti-VEGF therapy. According to certain aspects of the invention, subjects are identified based on their expression level of one or more predictive biomarkers. Favorable response to anti-VEGF therapy is indicated by high expression levels of certain biomarkers or by low expression levels of certain biomarkers. An exemplary predictive biomarker is VEGF-A. Also disclosed herein are prognostic biomarkers useful for identifying cancer-bearing subjects who are expected to have better relative survival outcomes.
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