首页> 外国专利> AN IMPROVED PROCESS FOR THE PREPARATION OF (1S, 4S, 7Z, 10S, 16E, 21R)-7- ETHYLIDENE-4,21-BIS(1-METHYLETHYL)-2-OXA-12,13-DITHIA-5, 8. 20, 23-TETRAAZA BICYCLO8.7.6TRICOS-16- ENE-3,6,9,19,22-PENTONE

AN IMPROVED PROCESS FOR THE PREPARATION OF (1S, 4S, 7Z, 10S, 16E, 21R)-7- ETHYLIDENE-4,21-BIS(1-METHYLETHYL)-2-OXA-12,13-DITHIA-5, 8. 20, 23-TETRAAZA BICYCLO8.7.6TRICOS-16- ENE-3,6,9,19,22-PENTONE

机译：制备（1S，4S，7Z，10S，16E，21R）-7-乙烯-4,21-BIS（1-甲基乙基）-2-OXA-12,13-DITHIA-5，8.的改进方法20，23-四氮杂双环[8.7.6] TRICOS-16- ENE-3,6,9,19,22-PENTONE

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摘要

The present invention is relates to an improved process for the preparation of (1S,4£7Z,10S,16£,21J) tetraazabi- cyclo[8.7.6]tricos-16- ene-3,659,19,22-pentone of formula I

机译：本发明涉及制备式的（1S，447Z，10S，16£，21J）四氮杂-环[8.7.6]三--16-烯-3,659,19,22-戊酮的改进方法一世

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公开/公告号IN2015CH05640A

专利类型
公开/公告日2017-07-07

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申请/专利号IN5640/CHE/2015
发明设计人 SRINIVASAN THIRUMALAI RAJAN;SAJJA ESWARAIAH;GHOJALA VENKAT REDDY;
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申请日2015-10-20
分类号A61K31;
国家 IN
入库时间 2022-08-21 13:38:47

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1. Involvement of extracellular signal-regulated kinase activation in human osteosarcoma cell resistance to the histone deacetylase inhibitor FK228 ((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8 ,20,23-tetraazabicyclo( [J] . Matsubara H, Watanabe M, Imai T, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2009,第3期

2. Chemoresistance to Depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-Ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] Is Mediated by Reversible MDR1 Induction in Human Cancer Cell Lines [J] . Jim J.Xiao, Ying Huang, Zunyan Dai, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2005,第1期