POLY (D, L-LACTIDE-CO-GLYCOLIDE) NANOPARTICLES CONTAINING CLOPIDOGREL BISULFATE FOR IMPROVED EFFICACY

摘要

Clopidogrel bisulfate is insoluble in aqueous solutions and the bioavailability after oral administration is poor. Poly (d, 1-lactide-co- glycolide) (PLGA) nanoparticles containing clopidogrel bisulfate have been successfully prepared to improve its efficacy. PLGA nanoparticles were prepared by using nanoprecipitation method and characterized. The in vivo studies gave promising data in terms of bleeding time, clotting time and platelet count and thus adding potential to therapeutic efficacy, decreased dose and lesser frequency of dosing, which in turn improves patient compliance. This revealed that the efficacy of Poly (d, 1-lactide-co-glycolide) nanoparticles containing clopidogrel bisulfate was significantly increased compared with that of pure drug suspension and marketed conventional dosage form. Our studies thus indicate that the Poly (d, 1-lactide-co-glycolide) nanoparticles can improve the bioavailability of clopidogrel bisulfate.