GYMNEMA SYLVESTRE EXTRACT WITH ENRICHED GYMNEMAGENIN SHOWS SUPERIOR ANTI DIABETIC EFFECT UNDER IN VITRO AND IN VIVO CONDITIONS

摘要

Extract of G. sylvestre leaves with rich glycoside molecules (gymnemic acid) was hydrolyzed to aglycone molecule (Gymnemagenin) by chemical method and by microbial method. Extract of G. sylvestre after hydrolysis showed better anti diabetic effect and good lipid profile in animals than animal treated with unhydrolyzed G. sylvestre leaves extract. Similar effects were observed under in vitro in Insulin-releasing RINm-5 F cells regarding insulin secretions. Extract of G. sylvestre after hydrolysis showed better insulin secretions than hydrolyzed G. sylvestre leaves extract