The present inventors employed cyclodextrins for use as a proteoglycan substitute to engineer a biomimetic collagen based matrix composition. The resulting incorporation of cyclodextrin in the inventive collagen compositions increased collagen thermal stability and reduced collagen fibrogenesis. As a result a thick transparent and mechanically strong collagen based composition was formed. This cyclodextrin collagen composition holds a great potential to be used as a therapeutic eye patch for corneal repair. Additionally the composition can support development of multi layered structures with different layers promoting different biological properties. Methods for making these inventive compositions and their use are also provided.
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