PROCESS FOR GREEN SYNTHESIS OF (1R)-2-{2-(4-AMINOPHENYL) ETHYL AMINO}-1- PHENYLETHANOL AND ITS DIHYDROCHLORIDE, AN INTERMEDIATE FOR MIRABEGRON

摘要

The present invention relates to a process for a green synthesis of (2R)-2-Phenyloxirane Formula 2. (2R) -2-Phenyloxirane Formula 2 is then condensed with an intermediate resulting from reaction of 4-Nitrophenylethylamine Hydrochloride with Benzyl halide. The intermediate resulting from the condensation reaction is reduced to produce (1JR) -2-{ [2- (4-aminophenyl) ethyl] amino}-l- phenylethanol and its Dihydrochlororide Formula 5 and Formula 5a.