首页> 外国专利> COMPOSITION FOR TREATING DIABETES CONTAINING LONG ACTING INSULIN ANALOG CONJUGATE AND LONG ACTING INSULIN SECRETION PEPTIDE CONJUGATE

COMPOSITION FOR TREATING DIABETES CONTAINING LONG ACTING INSULIN ANALOG CONJUGATE AND LONG ACTING INSULIN SECRETION PEPTIDE CONJUGATE

机译:用于治疗包含长效胰岛素类似物缀合物和长效胰岛素分泌肽缀合物的糖尿病的组合物

摘要

The present invention relates to a composition for preventing or treating diabetes containing long acting insulin analog and long acting insulin secretion peptide conjugates and a method for treating diabetes. More specifically the composition can remarkably improve compliance by inhibiting weight gain caused by the administration of insulin inhibiting emesis and nausea phenomena caused by the administration of an insulin secretion peptide and reducing the dose of insulin through the concomitant administration of the long acting analog conjugate and the long acting insulin secretion peptide conjugate. In addition the present invention relates to: a pharmaceutical composition for alleviating the side effects of pancreatic beta cells in a patient with diabetes containing a long acting insulin analog conjugate and a long acting insulin secretion peptide conjugate; and a method for alleviating the side effects of pancreatic beta cells in a patient with diabetes comprising a step of administering the composition wherein side effects particularly those such as pancreatic beta cell dysfunction pancreatic beta cell reduction lipotoxicity and glucotoxicity which are caused by the progression of diabetes are alleviated.
机译:本发明涉及用于预防或治疗糖尿病的包含长效胰岛素类似物和长效胰岛素分泌肽结合物的组合物,以及治疗糖尿病的方法。更具体地,该组合物可以通过抑制由于施用胰岛素抑制肽引起的体重增加和由胰岛素分泌肽的施用引起的恶心现象,并通过同时施用长效类似物缀合物和胰岛素来减少胰岛素的剂量,从而显着改善依从性。长效胰岛素分泌肽结合物。另外,本发明涉及:用于减轻糖尿病患者的胰腺β细胞的副作用的药物组合物,其包含长效胰岛素类似物结合物和长效胰岛素分泌肽结合物。减轻糖尿病患者的胰岛β细胞的副作用的方法,其包括以下步骤:给予组合物,其中特别是由糖尿病的进展引起的副作用,例如胰岛β细胞功能障碍,胰岛β细胞减少,脂质毒性和糖毒性。被缓解。

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