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OXOPIPERAZINE HELIX MIMETICS FOR CONTROL OF HYPOXIA INDUCIBLE GENE EXPRESSION
OXOPIPERAZINE HELIX MIMETICS FOR CONTROL OF HYPOXIA INDUCIBLE GENE EXPRESSION
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机译:氧哌嗪螺旋分子控制低氧诱导型基因的表达
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e.gThe present invention relates to oxopiperazines that mimic helix aB of the C terminal transactivation domain of HIF1a. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (. to reduce gene transcription treat or prevent disorders mediated by interaction of HIFla with CREB binding protein and/or p300 reduce or prevent angiogenesis in a tissue induce apoptosis and decrease cell survival and/or proliferation).
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