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A PROCESS FOR PREPARING ALUMINIUM CITRATE IN ORALLY ADMINISTRABLE FORM EFFECTIVE AGAINST GASTROINTESTINAL DISORDERS' .
A PROCESS FOR PREPARING ALUMINIUM CITRATE IN ORALLY ADMINISTRABLE FORM EFFECTIVE AGAINST GASTROINTESTINAL DISORDERS' .
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机译:制备一种有效的抗胃肠病的口服可调节形式的柠檬酸铝的方法”。
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摘要
Heretofore aluminium citrate was prepared from aluminium chloride by interacting them under vigorous agitation, preferably at low temperatures. Aluminium chloride of desirable grade is not readily available in this part of the country and this route is found to be lacking in cost effectiveness. As alternative route was being searched and this led to the present invention which relates to a process for preparing aluminium citrate in orally administrable form effective against gastrointestinal disorders, characterized in that the said process comprises - (a) dissolving potash alum [K2 Al2 (SO4)3, 24 H2O] by heating in water until a clear solution results; (b) adding solid or powdery sodium bicarbonate in water and boiling the mixture until dissolution results; (c) mixing solutions (a) and (b) in stoichiometric proportions under stirring and allowing the thus formed precipitate to settle for a period varying between 6 and 8 hours without agitation; (d) decanting the supernatant liquid followed by washing of the precipitate with distilled water until the wash liquid is free from SO4" ions; (e) adding citric acid solution to the reaction mass obtained from step (d), boiling the reaction medium to a temperature not exceeding 90°C under gentle stirring, and adjusting the pH between 6 and 7; (f) cooling the reaction medium to ambient temperature, filtering if necessary, and storing the final solution of aluminium citrate in orally administrable form followed by transferring the solution into suitable receptacles in predetermined volumes prior to dispatch to outlets.
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