PROBES AND PRIMERS FOR IDENTIFICATION OF MYCOBACTERIAL PROTEIN USEFUL AS POTENTIAL DRUG TARGETS

摘要

The present invention identifies set of primers used in the classification of potential drug target genes in leprosy genome. These genes have been selected from human on the basis of their over expression during the active stage of disease as compared to other selected genes of metabolism of the organism and having less then 44% homology within the human genome. These gene targets are used to find out the bacterial specific blocker to act as bactericidal drug by in-silico proteomic approaches (protein modeling and chemical database search).These gene targets could have broader application for drug development for tuberculosis and other mycobacterial diseases.