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PROCESS FOR THE PREPARATION OF SHIKIMIC ACID USEFUL FOR PRODUCTION OF AVIAN FLU DRUG TAMIFLU (OSELTAMIVIR),
PROCESS FOR THE PREPARATION OF SHIKIMIC ACID USEFUL FOR PRODUCTION OF AVIAN FLU DRUG TAMIFLU (OSELTAMIVIR),
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机译:制备用于生产禽流感药物达米氟(OSELTAMIVIR)的浮石酸的方法,
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摘要
This invention is directed to the production of shikimic acid from Illicium griffithii fruits. The method according to the invention is particularly applicable to the isolation of shikimic acid from Illicium griffithii fruits (seeds and pericarps). Yield is 12-18% w/w. Shikimic acid is useful as raw material for the production of oseltavir (Tamiflu) used against Avian Flu. It is also reported that its triacyl derivatives can inhibit blood platelet assembling and Thrombosis by affecting the metabolism of Arachidonic acid. Hitherto known commercial methods of production of shikimic acid from the fruits of star anise (Illicium verum) and sweet gum (Liquidambar styraciflua) gives only 3-7% and 1.5% respectively. The price of shikimic acid in the international market varies from US$ 45.00 to 1000.00 per Kg depending on demand. Further as per report published at the website www.livemint.com, China Government has imposed restriction on export of shikimic acid.
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