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GAS57 MUTANT ANTIGENS AND GAS57 ANTIBODIES,
GAS57 MUTANT ANTIGENS AND GAS57 ANTIBODIES,
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机译:GAS57突变抗原和GAS57抗体,
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pThe invention provides mutants of GAS57 which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes . The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections./p[WO2009034473A2]
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