'PEPTIDES HAVING PHARMACOLOGICAL ACTIVITY FOR TREATING DISORDERS ASSOCIATED WITH ALTERED CELL MIGRATION, SUCH AS CANCER',

摘要

pPeptides and their functionally equivalent derivatives, in salified or non-salified form, with the general formula LSUB1/SUB-XSUB1-/SUBXSUB2/SUB-XSUB3/SUB-XSUB4/SUB, wherein: LSUB1 /SUB is H, or acyl, or any natural or non-natural amino acid, optionally N-acylated, N-alkylated and/or Ca-alkylated; XSUB1/SUB and XSUB3/SUB, which are equal or different, are any natural or non-natural basic amino acid, optionally N-alkylated and/or Ca-alkylated; XSUB2/SUB is any natural or non-natural amino acid, optionally N-alkylated and/or Ca-alkylated, with the proviso that it is not glycine and amino acids mono-substituted on the a carbon atom with a linear or cyclic alkyl group, from 1 to 10 carbon atoms, and amino acids mono-substituted on the a carbon atom with a linear or cyclic alkyl group containing 4 to 10 carbon atoms, or amino acids mono-substituted on the a carbon atom with an alkyl group containing 1 to 8 carbon atoms, optionally substituted with a carbamoyl, hydroxyl or aromatic group; XSUB4/SUB is any natural or non-natural hydrophobic amino acid, optionally Ca-alkylated and/or amidated at the C-terminal end, or any hydrophobic amino alcohol, or a hydrophobic gem-diamine, optionally N'-alkylated or N'-acylated./p[WO2008017372A1]