1,4-DIHYDROPYRIDINE DERIVATIVE FOR PREVENTION OF DIABETIC CONDITIONS OF DNA BREAKS

摘要

Invention relates to medicine, internal medicine in particular to endocrinology and prevention of diabetes complications.It was observed that the compound AV-153-Na (Na 3,5-bis-ethoxycarbonyl-2,6-dimethyl-1,4-DHP-4-carboxylate) reduces the single-stranded DNA rupture levels in diabetes mellitus type 1 patient peripheral blood cell nuclei ex vivo by 3-hour incubation with AV-153-Na 5 nM concentrations.