human monoclonal antibody or its fragment from the antigene link which binds specifically to human the gremlin 1 useful for the treatment of fibrosis, cancer and inhibition of the angiogenese

摘要

the present invention relates to antibodies binding to human grem1 gremlin (1), and methods of use. according to some embodiments of the invention, the antibodies are antibodies that bind to a human grem1.the antibodies according to the invention are useful in inhibiting or neutralizing the activity of grem1, thus providing a means of treatment of a disease or disorder associated with grem1, such as fibrosis or cancer.according to some embodiments, the antibodies according to the present invention are used in the treatment of at least one symptom or complication of fibrosis of the liver, lung and kidney.