COMPARTMENTALIZED CONTINUOUS MICRO-REACTORS FOR THE PRODUCTION OF BIOPHARMACEUTICALS IN OVARY CELLS OF CHINESE HAMSTER.

摘要

The present invention refers to a group of micro-devices that a) have a plurality of cylindrical-shaped compartments obstructed by a central structure (toroidal or doughnut-type compartments); b) have a texture in the surface of the channel that promotes the cellular adherence and the retention or proliferation of the recombinant cells of the mammal, particularly but not exclusively, ovary cells of Chinese hamster; c) are fed with a culture medium in a continuous manner by some type of pumping device. This plurality of micro-devices may be used in screening applications for culturing recombinant cells of mammals, particularly but not exclusively CHO cells, or for the production of biopharmaceuticals or other recombinant proteins.