NASAL VACCINE AGAINST THE DEVELOPMENT OF ATHEROSCLEROSIS DISEASE AND FATTY LIVER.

摘要

The invention relates to a novel vaccine composition of micellar nanoparticles for intranasal administration for the treatment and/or prevention of atherosclerosis disease or non-alcoholic fatty liver resulting from an abnormal metabolism of circulating lipids. The vaccine composition of the invention is novel in that it uses lipids of archaebacteria, lysophosphati-dylcholine and phosphatidylcholine which confer stability on the nanoparticles and facilitate the presentation of the antigen in the form of its suitable secondary peptide structure. The invention also relates to a novel method for producing the vaccine composition, which can be used to obtain highly stable homogeneous micellar nanoparticles.