Organ care solution for ex-vivo machine perfusion of donor lungs

摘要

Discloses methods and systems for perfusing a donor lung in a lung perfusion circuit at or near physiologic conditions comprising: a single use disposable lung care module including an interface adapted for attachment to the single use module, and a lung chamber assembly having a first interface for allowing a flow of a perfusion solution into the lung and a second interface for allowing ventilation of the lung with a ventilation gas; and a drain system for draining a flow of perfusion solution from the lung chamber assembly; and the perfusion solution including dextran 40; sodium chloride; potassium chloride; magnesium sulfate anhydrate; disodium phosphate anhydrate; monopotassium phosphate; glucose monohydrate; milrinone (a phosphodiesterase inhibitor); nitroglycerin; insulin; a multi-vitamin; sodium bicarbonate; and methylprednisolone.