Interaction with inhibitors of kinase mitogen activated protein kinase (MNK) and Methods related thereto

摘要

Relates to compounds of formula (i) where W1 and W2 are o, s or N - oru00b4; ru00b4 is lower alkyl; and is N (R5) -, - O -, among others; r1 is H, Lower alkyl, among others; n is 1, 2 or 3; R2 and R3 are H, alkyl, or R2 and R3 with C form a cycloalkyl or heterociclilo R4A r4b are h; and Halogen, R5 is H, among others;Cyano or lower alkyl or R5 and R8 with Atoms that are United to form a heterociclilo condensate; R6, R7 and R8 are h, Hydroxy, among others. It is a Preferred compound: 2 - (6 - [4 - aminopirimidin - il) amino] - 5 - Chloro - 1 - methyl - spiro [2H - imidazo [1,5-a] pyridin-3 3,4u00b4 piperidin] - - - 1.5 - dione; among others. It also relates to a Pharmaceutical composition.These compounds inhibit the kinase mitogen activated protein kinase Interacting Protein (MNK) being useful in the treatment of diseases such as cancer