Pyrethroids as derivatives of Oregon receptor antagonists

摘要

It refers to the pyridine derivative in the preparation of (I), wherein a is a cyclohexane, isocyclohexane or cyclohexane, consisting of 3 to 12 optional substitute members; B is C (= O),In this paper, the author analyzes the characteristics of. In the heterocycle where e is cyclohexane or 5-6 members can be substituted optionally; G is substituted halogen, substituted hydroxyl, etc.; R1, R3, R4 and R6 are 0-2; R2 and R5 are 0 or 1; R1a, r1b, r1c, R2 and R3 are h, F, CN, NH2, etc. The most popular compound is formula (I),Page: 1There are others He also mentioned a pharmaceutical composer These compounds are antagonistic to Oregon receptors and are useful in the treatment of insomnia, anxiety and obsessive-compulsive disorder.