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methods for diagnosis, prognosis and therapeutic monitoring of neurological diseases, neurodegenerative diseases and inflammatory based on microrna content in microvesicles microglia
methods for diagnosis, prognosis and therapeutic monitoring of neurological diseases, neurodegenerative diseases and inflammatory based on microrna content in microvesicles microglia
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机译:小胶质细胞微RNA含量的神经系统疾病,神经退行性疾病和炎症的诊断,预后和治疗监测的方法
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摘要
The present invention describes a method for the in vitro diagnosis, prognosis and/or treatment monitoring of neurodegenerative, neurological and inflammation-based diseases, wherein the method comprises the steps: a) isolating microglial microvesicles (MVs) from biological fluids obtained from an individual; b) collecting the microRNA (miRNA) contained into said MVs; c) determining the expression profile of a predetermined set of miRNA; d) comparing said expression profile to one or several reference expression profiles, wherein the comparison of said determined expression profile to said one or several reference expression profiles allows for the diagnosis, prognosis and/or treatment monitoring of the disease.
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