Corneal administration of iontophoresis crosslinking agents for the treatment of keratoconus and related ophthalmic compositions

摘要

An ophthalmic composition for use in the treatment of keratoconus by corneal iontophoresis characterized in that it comprises: A. crosslinking agents that allow the reinforcement of the structure of the cornea affected by keratoconus through interweaving and increase the links (crosslinking) between collagen fibers of the cornea and which have buffering properties and whose initial pH value is between 5 and 6, where the crosslinking agent is riboflavin, or a solution of riboflavin phosphate, or dehydrated sodium salt of riboflavin phosphate, or dehydrated sodium salt of riboflavin phosphate H2O, or dehydrated sodium salt of riboflavin phosphate 2H2O, and B. a buffer system in variable amounts such as to reach the pH value of the final solution of 5.5, and C substances that promote the passage of riboflavin or other photosensitizing and photopolymerizing substances through the corneal epithelium, allowing I tend to absorb by the corneal stroma itself, called bio-enhancers, and / or D. photosensitive and photopolymerizing substances that can be easily absorbed by the epithelium and that, like riboflavin, can also be activated by light to form a corneal crosslink , called photopotentiators.