New derivatives of (1H-indol-3-ilmethyl) dimethylamine with blocking activity of voltage-dependent ca2 channels, preferably no-l, and its application in the treatment of diseases of the nervous system (Machine-translation by Google Translate, not legally binding)

摘要

New derivatives of (1H-indol-3-ilmetil) dimethylamine with blocking activity of voltage dependent ca2 channels, preferably no-l, and its application in the treatment of diseases of the nervous system. {image-01} The present invention relates to compounds of general formula (I), and their use in the manufacture of medicaments useful for the treatment of diseases of the central and peripheral nervous system, such as neurodegenerative diseases, stroke, epilepsy, migraine, pain neuropathic or, in general, any disease produced by the alteration of the biological functions on which said products act. One of the therapeutic strategies to treat these diseases is the reduction of the entrance of ca2 through voltage dependent ca2 channels (ccdv). Thus, the compounds claimed in this invention regulate the homeostasis of ca2 in excitable cells, which is altered in these conditions. Among all types of ccdv, the compounds of general formula (I) act preferentially by the so-called non-l, so they would lack peripheral side effects of hemodynamic type, where the ccdv type l are predominant. The present invention can be framed in the field of the pharmaceutical industry. (Machine-translation by Google Translate, not legally binding)