Therapeutic canine immunoglobulins and methods of use thereof

摘要

An antibody, a fusion protein or a binding fragment thereof for use in the therapeutic treatment of a canine in which target neutralization is desired in the absence of undesirable effector function, wherein said antibody, fusion protein or fragment Binding has a heavy chain constant domain comprising the amino acid sequence of SEQ ID NO: 8, SEQ ID NO: 11 or SEQ ID NO: 13, in which the amino acid sequence of the heavy chain minimizes the activation of functions immune system effectors downstream when the antibody, fusion protein or binding fragment binds with its target antigen.