Methods related to microRNA-21 and repair of disappearance in colorectal cancer

摘要

A composition of matter for use in the treatment of colorectal cancer (CRC) in a patient who has decreased expression of the hMSH2 protein (mismatch repair recognition protein complex (MMR)) and who responds more to treatment with 5- fluorouracil, the composition comprising: an effective amount of antisense miR-21 and a pharmaceutically acceptable formulation thereof, wherein miR-21 has SEQ ID. No.12.