Combination compositions of adenosine A1 agonists and carbonic anhydrase inhibitors to reduce intraocular pressure

摘要

An ophthalmic combination comprising ** Formula ** i) ((2R, 3S, 4R, 5R) -5- (6- (cyclopentylamino) -9H-purin-9-5 yl) -3,4-dihydroxytetrahydrofuran- 2-yl) methyl, or a pharmaceutically acceptable salt thereof, and ii) a carbonic anhydrase inhibitor selected from dorzolamide, brinzolamide, or acetazolamide, for use in reducing elevated intraocular pressure in an eye of a subject