TELOMERE RESTORATION AND EXTENSION OF CELL LIFE-SPAN IN ANIMALS CLONED FROM SENESCENT SOMATIC CELLS

摘要

This invention relates to methods for rejuvenating normal somatic cells andfor making normal somatic cells of a different type having the same genotypeas a normal somatic cell of interest. These cells have particular applicationin cell and tissue transplantation. Also encompassed are methods of re-cloningcloned animals, particularly methods where the offspring of cloned mammals aredesigned to be genetically altered in comparison to their cloned parent, e.g.,that are "hyper-young". These animals should be healthier and possessdesirable properties relative to their cloned parent. Also included aremethods for activating endogenous telomerase, EPC-1 activity, and or the ALTpathway and/or extending the life-span of a normal somatic cell, and othergenes associated with cell aging of proliferation capacity.