TARGETED GLYCOSAMINOGLYCAN POLYMERS BY POLYMER GRAFTING AND METHODS OF MAKING AND USING SAME

摘要

The present invention relates to methodology for polymer grafting by apolysaccharide synthase and, more particularly, polymer grafting using thehyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, inorder to create a variety of glycosaminoglycan oligosaccharides having anatural or chimeric or hybrid sugar structure with a targeted size that aresubstantially monodisperse in size.