MUCIN HYPERSECRETION INHIBITORS BASED ON THE STRUCTURE OF MANS-RELATED PEPTIDES AND METHODS OF USE

摘要

Peptides are provided that comprise less than 24 amino acids. The peptideshave an amino acid sequence selected from the group consisting of: (a) anamino acid sequence having from 4 to 23 contiguous amino acids of a referencesequence PEPTIDE 1; (b) an amino acid sequence substantially identical to thesequence defined in (a); and (c) a variant of the amino acid sequence definedin (a). Also provided is a non-myristoylated MANS peptide. Various methods ofusing the peptides are also provided.