HIV VACCINE BASED ON TARGETING MAXIMIZED GAG AND NEF TO DENDRITIC CELLS

摘要

The present invention includes compositions and methods for making and using avaccine that includes a DC-specificantibody or fragment thereof to which an engineered Gag antigen is attached toform an antibody-antigen complex, whereinthe Gag antigen is less susceptible to proteolytic degradation by eliminatingone or more proteolytic sites or a DC-specificantibody or fragment thereof to which an engineered Nef antigen is attached toform an antibody-antigen complex, wherein the Nefantigen comprises one or more codon usage optimization that increase antibody-antigen complex secretion, or both, wherein thevaccine is able to elicit an HIV-specific T cell immune response to Gag p17,Gag p24, Nef and/or Cy clin D1.