A COMPOSITION COMPRISING (-)-TRANS-3-(5,6-DIHYDRO-4H-PYRROLO 3,2,1-IJ QUINOLIN-1-YL)-4-(1H-INDOL-3-YL) PYRROLIDINE-2, 5-DIONE IN COMBINATION WITH A SECOND ANTI-PROLIFERATIVE AGENT

摘要

The present invention providesmethods of treating a cell proliferative disorder,such as a cancer, by administering to a subject inneed thereof a therapeutically effective amount ofa pyrroloquinolinyl-pyrrole-2,5-dione compoundor a pyrroloquinolinyl-pyrrolidine-2,5-dione compoundin combination with a therapeutically effectiveamount of a second anti-proliferative agent.