PREDICTIVE METHOD FOR CHARACTERIZING THE SENSITIVITY OF A TUMOUR IN RESPONSE TO A DNA-BREAKING TREATMENT

摘要

process for the evaluation of the response of a tumor to treatment when dna from a sample of the tumor cells in which: (a) preparing a cell sample from cells taken from the tumor; and (b), it shall submit the sample cell when the treatment is characterised by a dose of dna.(c) in the sample is determined, the number of nuclear cells, obtained with a marker ph2ax found the observation time t (such numbers are called, respectively, nph2ax (t)), the observation time t is the time t = 0 min (before administration to n the dose (d), and at least one selected from a time t = t1, t2.t3 and t4 after administration of the dose; and (d) determining at least one parameter or score to characterize the response of the dna sample processing when using at least the average numbers nph2ax (t), which is a fixed value (process) the time for which the rate you breaks dna reached its residual value.- t3 is a fixed value, which is the time for about 25 per cent of double stranded breaks (cbd) are repaired in control cells from patients radioru00e9sistants, t2 is a fixed value, which is the time for approximately 50 per cent of the cbd are repaired in c ellules controls from patients radioru00e9sistants.- t1 is a fixed value, which is the time for the number of cbd are peaked in control cells from patients radioru00e9sistants.