METHODS OF TREATING CELIAC DISEASE USING SMAD7 INHIBITION

摘要

The present invention relates to methods of treating, preventing, and/ormanaging celiac disease by inhibitingSMAD7. The invention is also directed to methods of monitoring effectivenessof treatment or management of celiac disease using aSMAD7 antisense oligonucleotide, as well as methods of regulating SMAD7antisense oligonucleotide treatment, based on analysisof Transforming Growth Factor-.beta. (TGF-.beta.) signaling activity.