The present invention relates to a method and apparatus for operating an unmanned smart car using biometric signal analysis, which analyze a biometric signal, provide information on the current situation in real time, and can automatically move to a location suitable for one's mood. The present invention provides a method of operating an unmanned smart car using biometric signal analysis, the method characterized by including the steps of: using a biometric signal sensing unit inside the unmanned smart car to sense a biometric signal of a user inside the unmanned smart car; using a sensing signal analyzing unit of the unmanned smart car to compare the biometric signal sensed through the biometric signal sensing unit to one or more of analysis data on the person's physical, mental, and psychological state, according to the user's gender, age, preferred rest areas, preferred food styles, and biometric signal which are stored in a memory unit, and analyzing same as data; using the controller of the unmanned smart car to show a rest area to the user inside the unmanned smart car according to the analyzed data; and using the controller of the unmanned smart car to carry out control for unmanned driving to the rest area through an unmanned driving unit for driving the smart car without a driver.
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