首页>
外国专利>
ETS FACTORS REGULATE NEURAL STEM CELL DEPLETION AND GLIOGENESIS IN RAS PATHWAY GLIOMA
ETS FACTORS REGULATE NEURAL STEM CELL DEPLETION AND GLIOGENESIS IN RAS PATHWAY GLIOMA
展开▼
机译:ETS因子调节RAS通路胶质瘤中神经干细胞的耗竭和糖原异生
展开▼
页面导航
摘要
著录项
相似文献
摘要
Described herein are composition and methods related to targeting the Nf1-Ras-Ets axis, that when perturbed, is identified as playing a role in initiation and maintenance in glioma. A postnatal, mosaic, autochthonous, glioma model that captures the first hours and days of gliomagenesis in more resolution than conventional genetically engineered mouse models of cancer demonstrates that disruption of the Nf1-Ras pathway in the ventricular zone at multiple signaling nodes uniformly results in rapid neural stem cell depletion, progenitor hyperproliferation, and gliogenic lineage restriction. By abolishing Ets subfamily activity, which is upregulated downstream of Ras, there is block of glioma initiation, thereby providing new therapeutic avenues for targeting glioma.
展开▼