THERAPIES UTILIZING COMPOUNDS TO FIBROBLAST GROWTH FACTOR RECEPTOR-3 (FGFR3)
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机译:利用化合物对成纤维细胞生长因子受体3(FGFR3)进行治疗
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摘要
The invention provides therapies utilizing conjugates that consist of a drug moiety agent and a cell binding agent that target human fibroblast growth factor receptor 3 (FGFR3). These conjugate therapeutic uses are designed and tailored to target a specific cell population and deliver a powerful cytotoxin inside the cell. The present invention is the use of these therapies in lung cancer, specifically those with a FGFR3-TACC gene fusion, bladder cancer, specifically those with a FGFR3-BAIAP2L1 gene fusion, and bladder cancer in combination with an anti-VEGFR2 antibody.
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