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METHODS OF TREATMENT WITH NATURAL KILLER CELLS MATCHED FOR KILLER IMMUNOGLOBULIN RECEPTOR TYPE
METHODS OF TREATMENT WITH NATURAL KILLER CELLS MATCHED FOR KILLER IMMUNOGLOBULIN RECEPTOR TYPE
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机译:杀死免疫球蛋白受体型的天然杀伤细胞的治疗方法。
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摘要
The present invention concerns methods of treating a disease such as leukemia in a subject by administering natural killer (NK) cells. In particular aspects, HLA-C1-licensed KIR2DL2/3 and KIR2DS2 NK cells are administered to a subject with an HLA-C genotype either homozygous or heterozygous for the C1 allele, or HLA-C2 licensed cells are administered to a subject with an HLA-C genotype homozygous for the C2 allele. In further aspects, the NK cells are genetically modified to express a chimeric antigen receptor and interleukin 15.
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