Aerosolization apparatus for inhalation profile-independent drug delivery

摘要

A powder aerosolization apparatus comprises a housing (110) comprising an outlet adapted to be inserted into a user's mouth and one or more bypass air openings. A receptacle support (135) within the housing supports a receptacle (130) containing a powder pharmaceutical formulation. A puncturing mechanism within the housing creates in the receptacle one or more inlet openings and one or more powder outflow openings (150), wherein the powder outflow openings have a total area of from 0.2 mm