Process for the enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo4.2.0octa-1,3,5-trien-7-yl) N-methyl methanamine, and application in the synthesis of ivabradine and salts thereof

摘要

#$%^&*AU2013206562B220170202.pdf#####PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-1-(3,4DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL) N-METHYL METHANAMINE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF Abstract A process for the enzymatic synthesis of the compound of formula (I), (7S)-1(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl) N-methyl methanamine: (I) (s and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.