MULTIPLE DRUG LIPID NANOPARTICLE COMPOSITION AND RELATED METHODS FOR EXTENDED DRUG LEVELS IN BLOOD AND LYMPH TISSUE

摘要

Provided are multi-drug lipid nanoparticles that stably incorporate multiple small molecule drugs with divergent hydrophobic and water solubility characteristics and related methods of making and using the same, The disclosed compositions and methods provide for enhanced stability of lipid nanoparticle drug formulations that can reliably provide drugs addressing different mechanistic targets with prolonged presence in the body for more efficacious treatment and avoidance of single drug resistance.