A method for treating cancer based on metallofullerene monocrystalline nanoparticles that specifically disrupt tumor blood vessels

摘要

Disclosed is a use of metallofullerene monocrystalline nanoparticles for the preparation of tumor vascular disrupting agents. The monocrystalline nanoparticles are water-soluble metallofullerene nanoparticles having negative charges on the surfaces thereof, the range of particle diameters thereof being from 50 to 250 nanometers. Additionally, the nanomaterials absorb external radiation energy and convert said energy into heat, and the volumes thereof rapidly expand when the temperature reaches the phase transition point. During treatment, metallofullerene monocrystalline nanoparticles are administrated to a tumor-bearing organism by means of injection; the metallofullerene monocrystalline nanoparticles reach tumor sites by means of blood circulation, and stay at the sites of pores and defects of the tumors; under the effect of the external radiation energy, the metallofullerene monocrystalline nanoparticles accumulate heat and the temperature increases, and the volumes of the nanoparticles sharply expand when the temperature exceeds the phase transition critical point, thereby causing changes in the shape, structure, or functions of the tumor vascular endothelial cells, disrupting the tumor blood vessels, and further starving the tumor cells.